Iowa State hosts Southern University at Hilton Coliseum — one of the most intimidating home venues in college basketball — where the Cyclones have a massive talent edge. While Wiggins (Achilles) and Toure (shoulder) are unavailable, ISU's roster still features proven contributors like Tamin Lipsey and a deep supporting cast capable of running up the score. Southern is a SWAC program with no business being on the floor with a Big 12 powerhouse in Ames, making the -36.5 spread eminently coverable.